ea0015oc8 | Young Endocrinologist prize session | SFEBES2008
Turban Sophie
, Ramage Lynne
, Paterson Janice
, Mullins John
, Seckl Jonathan
, Morton Nik
High systemic cortisol levels contribute to insulin resistance and may exacerbate the development of diabetes by impairing the insulin secretory response of the pancreatic beta-cells (β-cells). 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key modulator of glucocorticoid effect within target tissues and high adipose or liver levels of this enzyme may contribute to obesity and/or metabolic disease. We investigated cellular localization of 11β-HSD1 ...